Department of Systems Biology
Our focus is to decipher the genetic and molecular circuitry that is at the interface of host-pathogen interactions. We would like to understand how this circuitry controls cellular responses to infection, imparts selective pressure on viruses and affects disease progression. Using animal models of infectious disease, molecular biology, and genomic and computational methods, we seek to generate mechanistic models of the dynamic interactions between host and pathogen. The efforts are aimed at developing general strategies for the study of host-pathogen dynamics. A mechanistic understanding of these relationships provides important insights into cellular machinery that control basic cell biology and have broad implications in human translational immunology and infectious disease research.